Anal cancer is an uncommon type of cancer that occurs in the anal canal. The anal canal is a short tube at the end of your rectum through which stool leaves your body. Anal cancer can cause signs and symptoms such as rectal bleeding and anal pain. Most people with anal cancer are treated …
Therapeutic options for treatment of basal-like breast cancers remain limited. Here, we demonstrate that bromodomain and extra-terminal (BET) inhibition induces an adaptive response leading to MCL1 protein-driven evasion of apoptosis in breast cancer cells. Consequently, co-targeting MCL1 and BET is …
Sally C.M. Lau, 1Pengfei Sui,2 Haiquan Chen,6 J. Alan Diehl,7 Anil K. Rustgi,8 Adam J. Bass,8 John T. Poirier, ... lung basal progenitor cells,25 a hypothesized cell of origin for LUSC.26,27 Because the vast majority of KMT2D mutations co-occur with TP53 mutations (99 in 113 samples, 87.6%) (Fig-
10.3389/fncom.2021.678232. Many studies on the drift-diffusion model (DDM) explain decision-making based on a unified analysis of both accuracy and response times. This review provides an in-depth account of the recent advances in DDM research which ground different DDM parameters on several brain areas, including the cortex and basal …
Arjun Maitra 1, Madhav Basal, Anil Kapoor, Rakesh Biswas. Affiliation 1 Department of Physiology, People's College of Medical Sciences, Bhopal, India. PMID: 22798300 PMCID: PMC3038018 DOI: 10.1136/bcr.04.2009.1797 No abstract available. Publication types Case Reports ...
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Ashley M Lucke 1 2, Anil N Shetty 3, Joseph L Hagan 4, Allison Walton 4, Tiffany D Stafford 4, Zili D Chu 5, Christopher J Rhee 4, Jeffrey R Kaiser 6 ... Eleven neonates with HIE underwent MR spectroscopy of the basal ganglia and white matter. We compared metabolite concentrations during therapeutic hypothermia and post-therapeutic ...
Kotaro Sasaki, Sheldon I. Bastacky, Debra L. Zynger, Anil V. Parwani, Use of Immunohistochemical Markers to Confirm the Presence of Vas Deferens in ... stained), 2+ (11%–50% of cells stained), and 3+ (>50% of cells stained). In cases in which the discrimination of basal cells vs surface columnar cells was not possible owing to crushed …
Cancer is a serious and significantly progressive disease. Next to cardiovascular disease, cancer has become the most common cause of mortality in the entire world. Several factors, such as environmental factors, habitual activities, genetic factors, etc., are responsible for cancer. Many cancer patients seek alternative and/or …
We observed that Arabidopsis hsc70-1 mutant seedlings show elevated basal heat tolerance compared with wild-type. Over-expression of Hsc70-1 resulted in increased heat sensitivity. Hsp101 transcript and protein levels were increased during non-heat stress (HS) and post-HS conditions in hsc70-1 mutant seedlings.
The SCJ links the fore- and hindstomach in mice, in contrast to linking the esophagus and stomach in humans. The transitional epithelium in the SCJ is maintained by transitional basal cells (TBCs), which are distinct from SBCs (Figure 1 F; Jiang et al., 2017).TBCs have emerged, along with gastric cardia stem cells, as a possible source for …
Methods: Histopathologic analysis of basal layer thickness and collagen accumulation was performed on the biopsy specimens of normal individuals, EE patients, and mouse esophageal tissue sections following experimental induction of EE in wild-type, eosinophil lineage-deficient, interleukin (IL)-5-deficient, and IL-5 transgenic mice, with the ...
Causes. Basal cell carcinoma occurs when one of the skin's basal cells develops a mutation in its DNA. Basal cells are found at the bottom of the epidermis — the outermost layer of skin. Basal cells produce new skin cells. As new skin cells are produced, they push older cells toward the skin's surface, where the old cells die and are sloughed ...
Updated: Sep 26, 2021, 10:21 PM IST. The Union Public Service Commission (UPSC) released the results of the Civil Services (CSE) Main examination 2020 on Friday evening (September 24). The exam was topped by Shubham Kumar from Bihar, the second place was bagged by Jagrati Awasthi and Ankita Jain, secured all-India third rank.
The medulla oblongata is the connection between the brainstem and the spinal cord, carrying multiple important functional centers. It is comprised of the cardiovascular-respiratory regulation system, descending motor tracts, ascending sensory tracts, and origin of cranial nerves IX, X, XI, and XII. Motor neurons cross from the left …
Description. A 50-year-old woman who was a homemaker presented to us with a history of gradual weight gain over the last 3 years, and on examination was found to have a puffy face (figure 1) along with marked coarsening of her skin (figure 2).On neurological examination the most remarkable finding was a delayed tendon reflex prominent in the …
The basal ganglia (pronounced "bay-sal" "gang-lee-uh") are a group of structures near the center of your brain that form important connections. These connections allow different areas of your brain to work together. The basal ganglia manage the signals your brain sends that help you move your muscles. Advertisement.
The standard treatment for anal cancers that cannot be removed without harming the anal sphincter is external beam radiation therapy (EBRT) combined with chemo (called chemoradiation). In chemoradiation, the 2 treatments are given over the same time period. The chemo is usually 5-FU with mitomycin.
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